Testos (Testosterone Enanthate)

About the Product

Testos is a research compound from Driada Medical, presented as a solution for intramuscular injection containing Testosterone Enanthate. Testosterone Enanthate is a long-acting ester prodrug of the endogenous androgen hormone, testosterone. The enanthate ester is a seven-carbon chain attached at the 17-beta-hydroxy group of the testosterone molecule, which significantly slows the release of the active hormone into the bloodstream following administration. This results in a sustained duration of action, typically requiring administration every 2-4 weeks in clinical settings.

The product is intended for laboratory research use only and features an integrated QR code on the packaging for detailed product verification. Its empirical formula is C₂₆H₄₀O₃ with a molecular weight of 400.66 g/mol.

• Product Name: Testos (Testosterone Enanthate)

• Brand: Driada Medical

• Form: Injectable solution (oil-based)

• For Research Use Only.

Research Applications & Mechanism of Action

• Androgen Receptor Agonist: Testosterone Enanthate functions as a potent agonist at the androgen receptor (AR). Upon administration, the ester is cleaved by esterases in vivo, releasing active testosterone which binds to ARs in target tissues. This binding initiates a signaling cascade that regulates gene transcription via hormone response elements (HREs), mediating androgenic effects.

• Protein Anabolism: By activating the androgen receptor, testosterone promotes protein anabolism (building up of proteins) and reduces protein catabolism (breakdown), which can be studied in models of muscle physiology and metabolic research.

• Metabolic Research: Testosterone plays a significant role in systemic metabolism. Research applications can include studying its effects on lipid profiles, including its observed impact on increasing triglycerides and VLDL while decreasing HDL in animal models. It also affects glucose homeostasis, insulin sensitivity, and erythropoiesis.

• Reproductive System Research: Testosterone Enanthate has been extensively studied for its effects on the hypothalamic-pituitary-gonadal axis, including spermatogenesis suppression and restoration of reproductive function in hypogonadal models.

• Pharmacokinetics: The compound is designed for slow, sustained absorption when administered in an oil vehicle. It exhibits a half-life of approximately 7-9 days and is metabolized primarily in the liver, with about 90% of a dose excreted in urine as conjugates.

Research & Scientific Background

• Clinical Context: Testosterone Enanthate is a well-characterized compound with an established history in the clinical management of male hypogonadism, including primary hypogonadism (testicular failure) and hypogonadotropic hypogonadism (pituitary/hypothalamic dysfunction). In clinical settings, it is typically administered at doses of 50-200mg every 2-4 weeks.

• Male Hormonal Contraception Research: WHO conducted large multicenter trials using intramuscular testosterone enanthate 200mg weekly as a contraceptive, demonstrating efficacy with 95-98% of men achieving azoospermia or severe oligozoospermia. This makes it a relevant tool for studying hormonal contraception mechanisms.

• Non-Human Primate Studies: Research in cynomolgus and rhesus monkeys has characterized the pharmacokinetics of testosterone enanthate, showing serum testosterone levels rise to 400-800% of baseline within 24 hours, remain elevated for 3-5 days, and return to baseline after 4-5 weeks. Studies have also demonstrated its efficacy in restoring reproductive function in hypogonadal models.