TB-500

About the Product

Genetic Labs TB-500 is a high-purity synthetic peptide (research grade) supplied in a vial containing 10mg of lyophilized (freeze-dried) powder. TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in virtually all human cells. It is a potent actin-binding peptide that plays a crucial role in cell migration, proliferation, and differentiation. The synthetic variant, TB-500, is specifically engineered to enhance the regenerative and reparative properties of the native peptide for research applications.

Kit Contents:

• 1 Vial with 10mg TB-500 (Lyophilized Powder)

• 1 Vial with 3mL Bacteriostatic Water (Diluent)

For Laboratory Research Use Only. Not for human consumption.

Benefits (Research Scope)

• Actin-Binding Peptide: TB-500 binds to actin, a key protein in the cytoskeleton, promoting cell migration, adhesion, and survival. This makes it a valuable tool for studying wound healing, tissue regeneration, and cellular repair mechanisms.

• Versatile Research Tool: Suitable for a wide range of studies, including:

  • Wound Healing & Tissue Repair: Research into accelerated wound closure, angiogenesis (new blood vessel formation), and extracellular matrix remodeling.

  • Muscle & Tendon Regeneration: Studies on skeletal muscle, cardiac muscle, and tendon repair following injury or degenerative conditions.

  • Neuroprotection: Investigation into neural repair, axonal growth, and neuroinflammation modulation following spinal cord injury or neurodegenerative models.

  • Anti-Inflammatory Research: Studies on the regulation of inflammatory cytokines and the promotion of an anti-inflammatory microenvironment.

  • Cardiovascular Research: Research into cardiac repair following myocardial infarction (heart attack), promoting survival of cardiomyocytes and reducing scar tissue formation.

• Practical Formulation: The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both in vitro and in vivo experiments.

Research & Science

TB-500 (Thymosin Beta-4) is one of the most extensively studied regenerative peptides, with a wealth of preclinical research supporting its multiple biological functions.

• Mechanism of Action: TB-500 binds to monomeric actin (G-actin), sequestering it and regulating actin polymerization dynamics. This interaction controls cell motility, cytoskeletal reorganization, and cell survival pathways. Additionally, TB-500 modulates inflammatory responses by downregulating pro-inflammatory cytokines (such as TNF-α and IL-1β) and upregulating anti-inflammatory mediators, while also promoting angiogenesis through upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs).

• Regenerative Properties: Research has demonstrated that TB-500 promotes the proliferation and migration of endothelial cells, keratinocytes, and fibroblasts to wound sites, accelerating tissue repair. It also plays a role in promoting hair follicle stem cell activation and hair growth in research models.

• Cardioprotective Research: Studies have shown that TB-500 improves cardiac function, reduces scar tissue, and enhances vascularization in animal models of myocardial infarction, making it a promising compound for cardiovascular repair research.

• Musculoskeletal Research: TB-500 has been investigated for its ability to improve healing of muscle tears, tendon injuries, and ligament damage, with studies showing improved collagen deposition, reduced scar tissue, and enhanced functional recovery.

• Neuroregenerative Research: Emerging research explores TB-500's role in promoting neurite outgrowth, protecting against excitotoxicity, and modulating inflammation in models of stroke, traumatic brain injury, and spinal cord injury.

• Focus on Genetic Variability: Current research is exploring how genetic factors, such as polymorphisms in actin-related genes or inflammatory pathway genes, may influence individual responses to TB-500, paving the way for personalized regenerative medicine approaches.