SLU-PP-332

About the Product

Genetic Labs SLU-PP-332 is a high-purity synthetic compound (research grade) supplied in a vial containing 5mg of lyophilized (freeze-dried) powder. SLU-PP-332 is a novel, non-hormonal, small molecule that functions as a potent pan-agonist of the estrogen-related receptors (ERRs) , specifically targeting ERRα, ERRβ, and ERRγ. These receptors are key regulators of mitochondrial biogenesis, oxidative metabolism, and energy homeostasis. SLU-PP-332 has emerged as a groundbreaking research tool for studying metabolic adaptation, exercise mimetics, and mitochondrial function.

Kit Contents:

• 1 Vial with 5mg SLU-PP-332 (Lyophilized Powder)

• 1 Vial with Bacteriostatic Water (Diluent)

For Laboratory Research Use Only. Not for human consumption.

Benefits (Research Scope)

• Pan-ERR Agonist: SLU-PP-332 is the first-in-class small molecule that selectively and potently activates all three ERR isoforms (ERRα, ERRβ, and ERRγ). This unique activity allows researchers to study the coordinated activation of the entire ERR transcriptional network, which controls mitochondrial function, fatty acid oxidation, and glucose metabolism.

• Exercise Mimetic Research: SLU-PP-332 has been shown to induce a transcriptional and metabolic profile similar to endurance exercise, including increased oxidative capacity, enhanced fatty acid oxidation, and improved metabolic flexibility. This makes it a powerful tool for studying exercise mimetics and metabolic adaptations without physical training.

• Versatile Research Tool: Suitable for a wide range of studies, including:

  • Metabolic Disorders: Research into obesity, type 2 diabetes, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD).

  • Mitochondrial Biology: Studies on mitochondrial biogenesis, oxidative phosphorylation, and mitochondrial dysfunction.

  • Muscle Physiology: Research into skeletal muscle adaptation, endurance performance, and muscle wasting conditions (sarcopenia, cachexia).

  • Cardiovascular Research: Studies on cardiac metabolism, heart failure, and ischemic heart disease.

  • Aging & Longevity: Investigation into age-related metabolic decline and mitochondrial dysfunction.

  • Cancer Metabolism: Research into metabolic reprogramming in cancer cells and potential therapeutic targets.

• Practical Formulation: The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both in vitro and in vivo experiments.

Research & Science

SLU-PP-332 is a revolutionary small molecule that has garnered significant attention in the scientific community for its ability to mimic the beneficial effects of exercise at the molecular level.

• Mechanism of Action: SLU-PP-332 binds to the ligand-binding domain of all three ERR isoforms, inducing a conformational change that recruits coactivators (such as PGC-1α) and activates transcription of target genes. These target genes include those involved in:

  • Mitochondrial biogenesis (e.g., PGC-1α, NRF1, TFAM)

  • Fatty acid oxidation (e.g., CPT1B, MCAD, PDK4)

  • Oxidative phosphorylation (e.g., subunits of complexes I-V)

  • Glucose metabolism (e.g., GLUT4, pyruvate dehydrogenase)

  • Antioxidant defense (e.g., SOD2, catalase)

• Exercise-Mimetic Effects: Preclinical studies have demonstrated that SLU-PP-332:

  • Increases oxygen consumption and metabolic rate in vivo.

  • Enhances fatty acid oxidation and reduces lipid accumulation in skeletal muscle and liver.

  • Improves glucose tolerance and insulin sensitivity in diet-induced obesity models.

  • Increases endurance capacity in animal models without physical training.

  • Prevents weight gain and reduces adiposity in high-fat diet-fed animals.

• Metabolic Disease Research: SLU-PP-332 has shown remarkable efficacy in reversing metabolic dysfunction in animal models of obesity and type 2 diabetes, including significant reductions in fasting glucose, insulin, and triglycerides, as well as improvement in hepatic steatosis.

• Muscle Wasting Research: Studies have demonstrated that SLU-PP-332 can preserve muscle mass and function in models of sarcopenia and cachexia, offering potential for research into age-related and disease-related muscle loss.

• Cardioprotective Research: SLU-PP-332 has been investigated for its ability to improve cardiac function, enhance cardiac mitochondrial respiration, and protect against ischemic injury in models of heart failure.

• Aging & Longevity: As ERR activity declines with age, SLU-PP-332 is being studied as a potential intervention to counteract age-related metabolic decline and improve healthspan.

• Focus on Genetic Variability: Current research is exploring how genetic variations in ERR target genes, PGC-1α, and other metabolic pathway genes may influence individual responses to SLU-PP-332, paving the way for personalized metabolic interventions.

Important Note on Kit Contents

Please verify the kit contents as listed in the image:

• 1 x Vial SLU-PP-332 (Lyophilized Powder) 5mg

• 1 x Vial Bacteriostatic Water (Diluent) 3mL (Note: The text in the image appears to have a typo. It should read "Bacteriostatic Water" as per standard practice.)