Mastelad (Drostanolone Propionate)

About the Product

Mastelad is a research compound from Driada Medical, presented as a solution for intramuscular injection containing Drostanolone Propionate. Drostanolone Propionate is a synthetic androgen and anabolic steroid (AAS) derived from dihydrotestosterone (DHT). It is a 5α-reduced androgen, meaning it is not aromatized to estrogen, making it a valuable research tool for studying androgenic effects without estrogenic complications. The propionate ester provides a short to medium duration of action, allowing for controlled administration in research protocols.

The product is intended for laboratory research use only and features an integrated QR code on the packaging for detailed product verification. Its empirical formula is C₂₃H₃₆O₃ with a molecular weight of 360.53 g/mol.

• Product Name: Mastelad (Drostanolone Propionate)

• Brand: Driada Medical

• Form: Injectable solution (oil-based)

• For Research Use Only.

Research Applications & Mechanism of Action

• DHT-Derived Androgen: Drostanolone Propionate is a synthetic androgen derived from dihydrotestosterone (DHT). As a 5α-reduced steroid, it is not aromatizable to estrogen, making it a valuable research tool for studying pure androgenic effects without the confounding variables of estrogenic activity.

• Androgen Receptor Agonist: Drostanolone Propionate functions as a potent agonist at the androgen receptor (AR). Upon administration, the propionate ester is cleaved by esterases, releasing active drostanolone which binds to ARs in target tissues. This binding initiates a signaling cascade that regulates gene transcription via hormone response elements (HREs), mediating androgenic effects.

• Non-Aromatizable Profile: The absence of aromatization to estrogen distinguishes drostanolone from testosterone derivatives, allowing researchers to study:

  • Pure androgenic effects without estrogenic side effects.

  • Androgen receptor signaling in isolation from estrogen receptor activation.

  • Tissue-specific effects of androgens.

  • Comparative studies with aromatizable and non-aromatizable androgens.

• Protein Anabolism: Drostanolone promotes protein anabolism (building up of proteins) and reduces protein catabolism (breakdown), which can be studied in models of muscle physiology and metabolic research.

• Metabolic Research: Studies can include investigating effects on:

  • Lipid metabolism and adipocyte function.

  • Glucose metabolism and insulin sensitivity.

  • Nitrogen retention and protein synthesis.

• Receptor Binding Studies: The compound is used in research investigating:

  • Androgen receptor binding affinity and selectivity.

  • Structure-activity relationships of androgen receptor ligands.

  • Competitive binding studies with other androgens.

Research & Scientific Background

• Chemical Background: Drostanolone is a 5α-reduced derivative of testosterone, with a methyl group at the 2-position and a hydroxyl group at the 17β-position. The propionate ester is formed by esterification at the 17β-hydroxyl group.

• Clinical Context: Drostanolone Propionate has been studied in clinical research contexts, particularly in relation to:

  • Treatment of advanced breast cancer in postmenopausal women (historically).

  • Androgen replacement therapy research.

  • Effects on erythropoiesis.

• Non-Aromatizable Androgen Research: As a non-aromatizable androgen, Drostanolone Propionate is a valuable tool for studying:

  • Androgen Receptor Signaling: Investigating the molecular mechanisms of androgen action without estrogenic cross-talk.

  • DHT Receptor Binding: Studying the binding characteristics of DHT-derived compounds to the androgen receptor.

  • Pure Androgenic Effects: Understanding the effects of androgens in the absence of estrogenic activity.

• Muscle Physiology Research:

  • Skeletal Muscle Studies: Investigating the effects of androgens on muscle protein synthesis, satellite cell activation, and muscle fiber type composition.

  • Myogenic Differentiation: Studying the role of androgens in muscle cell differentiation and development.

• Metabolic Research:

  • Adipose Tissue: Investigating the effects of androgens on adipocyte metabolism, lipolysis, and fat distribution.

  • Insulin Sensitivity: Studying the impact of non-aromatizable androgens on glucose homeostasis.

• Endocrinology Research:

  • Hypothalamic-Pituitary-Gonadal Axis: Studying the suppression of gonadotropins and the feedback mechanisms of androgens.

  • Hormonal Regulation: Investigating the interplay between androgens and other hormones.