Liothymed (Triiodothyronine)

About the Product

Liothymed is a research compound from Driada Medical, containing Triiodothyronine (T3) , specifically the active form L-liothyronine . T3 is one of the two major hormones produced by the thyroid gland and is the biologically active form of thyroid hormone, responsible for the vast majority of the physiological effects attributed to thyroid function .

The compound is a synthetic version of endogenous T3, a 3,5,3′-triiodothyronine molecule with the molecular formula C₁₅H₁₂I₃NO₄ and a molecular weight of approximately 651 g/mol . It functions by binding to nuclear thyroid hormone receptors (TRs), acting as a ligand-dependent transcription factor that regulates the expression of genes involved in metabolism, growth, and development .

The product is intended for laboratory research use only and features an integrated QR code on the packaging for detailed product verification.

• Product Name: Liothymed (Triiodothyronine / L-Liothyronine)

• Brand: Driada Medical

• Form: Solution for research applications

• CAS Number: 6893-02-3 (L-T3)

• For Research Use Only.

Research Applications & Mechanism of Action

• Nuclear Thyroid Hormone Receptor Agonist: Triiodothyronine functions as a potent agonist at nuclear thyroid hormone receptors (TRα and TRβ) . Upon binding to these receptors, the T3-TR complex translocates to the nucleus, binds to thyroid hormone response elements (TREs) on DNA, and recruits coactivators or corepressors to modulate the transcription of target genes . This genomic action regulates a wide array of physiological processes, including basal metabolic rate, thermogenesis, and mitochondrial biogenesis .

• Metabolic Rate & Energy Homeostasis Research: T3 is a master regulator of metabolic rate and energy expenditure. Research applications include studying its effects on mitochondrial function, oxidative phosphorylation, and whole-body metabolism . Studies have shown that T3 treatment enhances mitochondrial respiration and autophagy, making it a key compound for metabolic research .

• Lipolysis & Lipid Metabolism Research: T3 promotes lipolysis (fat breakdown) and fatty acid oxidation, making it relevant for studies on adipocyte function, lipid metabolism, and body composition .

• Cardiovascular & Neurological Research: T3 is essential for normal cardiac function and cognitive performance. Research uses include investigating T3's effects on cardiac contractility, heart rate, and neurocognitive function, as well as its interaction with the hypothalamic-pituitary-thyroid (HPT) axis .

• Aging & Longevity Research: Recent research has highlighted T3's role in modulating aging pathways, including mechanistic target of rapamycin (mTOR), AMPK, IGF-1, sirtuins, and FOXO transcription factors. Studies have explored how subclinical variations in T3 levels may affect healthspan, cognitive preservation, and mitochondrial integrity, providing avenues for research into healthy aging and metabolic resilience .

• Drug Metabolism & Pharmacogenomics Research: Emerging research has identified genetic polymorphisms in deiodinase enzymes (e.g., DIO2 Thr92Ala) that may affect the peripheral conversion of T4 to T3 . This has led to research exploring how genetic factors influence individual responses to thyroid hormones and the potential for personalized endocrine optimization .

Research & Scientific Background

• Physiological Context: The thyroid gland primarily secretes thyroxine (T4), a prohormone that must be converted in peripheral tissues into the active form, T3, via deiodinase enzymes (DIO1, DIO2) . T3 binds to thyroid hormone receptors with significantly higher affinity than T4 and mediates the majority of thyroid hormone action . Normal serum T3 levels are tightly regulated by the HPT axis, with TSH serving as the primary feedback signal.

• Pharmacokinetics: Synthetic L-liothyronine (T3) has a rapid onset of action and a relatively short half-life (approximately 24 hours) compared to T4 . It is absorbed quickly and, due to its short duration, can cause fluctuations in serum T3 levels throughout the day in research models . These pharmacokinetic properties make T3 a valuable tool for studying acute thyroid hormone effects but also require careful dosing and monitoring in long-term experiments .

• T3 vs. T4 Research: While T4 monotherapy is the clinical standard for hypothyroidism, a subset of patients continue to experience symptoms despite normalized TSH levels . Research is exploring the physiological distinctions between T4 and T3, including the tissue-specific roles of deiodinase enzymes and the potential benefits of T3-containing therapies in certain research models .

• Thyroid Hormone & Aging: Recent mechanistic studies have begun to characterize the relationship between T3, cellular metabolism, and longevity . T3 is a key modulator of metabolic flexibility and mitochondrial health, and altered thyroid function has been paradoxically associated with increased longevity in some populations . This line of research is exploring how thyroid hormone levels affect pathways such as mTOR, AMPK, and mitochondrial biogenesis, which are central to aging biology .