IGF-1 LR3

About the Product

Genetic Labs IGF-1 LR3 is a high-purity synthetic peptide (research grade) supplied in a vial containing 1mg of lyophilized (freeze-dried) powder. IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a modified analog of endogenous insulin-like growth factor-1 (IGF-1), a 70-amino-acid peptide hormone that plays a central role in growth, development, and cellular metabolism. The "LR3" modification refers to an arginine (R) substitution at position 3 and a 13-amino-acid N-terminal extension, which significantly enhances the peptide's biological activity and half-life by reducing its binding affinity to IGF-binding proteins (IGFBPs). This makes IGF-1 LR3 a highly potent and valuable research tool for studying cellular growth, differentiation, and metabolism.

Kit Contents:

• 1 Vial with 1mg IGF-1 LR3 (Lyophilized Powder)

• 1 Vial with 3mL Bacteriostatic Water (Diluent)

For Laboratory Research Use Only. Not for human consumption.

Benefits (Research Scope)

• Enhanced IGF-1 Analog: IGF-1 LR3 is a synthetic analog of endogenous IGF-1 engineered for enhanced potency and extended biological activity. The LR3 modification reduces binding to IGF-binding proteins (IGFBPs), resulting in increased bioavailability, prolonged half-life, and greater activation of the IGF-1 receptor (IGF-1R) compared to native IGF-1.

• Versatile Research Tool: Suitable for a wide range of studies, including:

  • Cell Biology: Research into cell proliferation, differentiation, apoptosis, and survival signaling pathways.

  • Muscle Physiology: Studies on muscle growth, hypertrophy, protein synthesis, and muscle wasting conditions (sarcopenia, cachexia).

  • Metabolic Disorders: Research into insulin resistance, glucose metabolism, lipid metabolism, and diabetes.

  • Bone & Cartilage Research: Studies on bone formation, cartilage repair, and skeletal development.

  • Neurobiology: Investigation into neuronal survival, neuroprotection, and neural regeneration.

  • Aging Research: Studies on age-related decline in IGF-1 signaling, cellular senescence, and tissue regeneration.

  • Cancer Research: Investigation into IGF-1R signaling in tumor growth, metastasis, and therapeutic resistance.

  • Stem Cell Research: Studies on stem cell proliferation and differentiation.

• Practical Formulation: The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both in vitro and in vivo experiments.

Research & Science

IGF-1 LR3 is one of the most potent and widely studied growth factors in biomedical research, with a robust body of literature supporting its applications across multiple disciplines.

• Mechanism of Action: IGF-1 LR3 acts as a potent agonist at the IGF-1 receptor (IGF-1R), a transmembrane receptor tyrosine kinase that shares structural and functional homology with the insulin receptor. Upon binding, IGF-1 LR3 activates downstream signaling cascades, including:

  • PI3K/Akt Pathway: Promotes cell survival, proliferation, and protein synthesis; inhibits apoptosis.

  • MAPK/ERK Pathway: Regulates cell proliferation, differentiation, and gene expression.

  • mTOR Pathway: Stimulates protein synthesis and cellular growth.

• Enhanced Potency: The LR3 modification (arginine substitution and N-terminal extension) reduces the peptide's affinity for IGF-binding proteins (IGFBPs) by approximately 100-fold compared to native IGF-1. This results in:

  • Increased bioavailability and prolonged half-life.

  • Greater potency in activating IGF-1R and downstream signaling.

  • Enhanced biological activity in promoting cell growth and metabolism.

• Muscle Research: Studies have demonstrated that IGF-1 LR3:

  • Stimulates skeletal muscle hypertrophy and protein synthesis.

  • Promotes muscle regeneration and repair following injury.

  • Prevents muscle wasting in models of sarcopenia and cachexia.

  • Increases muscle fiber size and satellite cell activation.

• Metabolic Research: IGF-1 LR3 has been shown to:

  • Enhance glucose uptake and metabolism in muscle and adipose tissue.

  • Improve insulin sensitivity and glucose tolerance.

  • Promote lipid metabolism and fatty acid oxidation.

  • Modulate energy homeostasis and metabolic efficiency.

• Bone & Cartilage Research: IGF-1 signaling is critical for:

  • Osteoblast proliferation and bone formation.

  • Chondrocyte proliferation and cartilage matrix synthesis.

  • Skeletal growth and bone mineral density regulation.

• Neurobiology Research: Studies suggest that IGF-1 LR3:

  • Promotes neuronal survival and axonal growth.

  • Protects against neurotoxicity and apoptosis in neurodegeneration models.

  • Supports neural stem cell proliferation and differentiation.

• Aging Research: IGF-1 signaling is implicated in the aging process, with research focusing on:

  • Age-related decline in IGF-1 levels and activity.

  • Role in cellular senescence and tissue regeneration.

  • Potential interventions to counteract age-related muscle and bone loss.

• Cancer Research: Due to its role in cell proliferation and survival, IGF-1 LR3 is used to:

  • Study IGF-1R signaling pathways in cancer cells.

  • Investigate tumor growth and metastasis mechanisms.

  • Evaluate therapeutic targeting of IGF-1R in oncology research.

• Focus on Genetic Variability: Research is exploring how genetic polymorphisms in the IGF-1 gene, IGF-1R gene, and related signaling pathway genes may influence individual responses to IGF-1 LR3 and susceptibility to growth-related disorders.

Important Note on Research Applications

IGF-1 LR3 is a highly potent peptide. When conducting research:

• Exercise caution with dosing: Due to its enhanced potency, careful dose titration is recommended in experimental models.

• Monitor metabolic effects: IGF-1 LR3 can significantly affect glucose metabolism; this should be considered in research design.

• Appropriate controls: Due to its potent growth-promoting effects, appropriate positive and negative controls are essential in experimental design.