AOD9604

About the Product

Genetic Labs AOD9604 is a high-purity synthetic peptide (research grade) supplied in a vial containing 5mg of lyophilized (freeze-dried) powder. AOD9604 is a modified fragment of human growth hormone (hGH), specifically consisting of amino acids 177-191 of the C-terminal region of the hGH molecule. This 15-amino-acid peptide retains the lipolytic (fat-burning) properties of full-length growth hormone without exhibiting its growth-promoting (mitogenic) effects, including insulin-like growth factor-1 (IGF-1) elevation and insulin resistance. This unique profile makes AOD9604 a valuable research tool for studying metabolism, obesity, lipid regulation, and energy homeostasis, isolated from the growth-promoting effects of native growth hormone.

Kit Contents:

• 1 Vial with 5mg AOD9604 (Lyophilized Powder)

• 1 Vial with Bacteriostatic Water (Diluent)

For Laboratory Research Use Only. Not for human consumption.

Benefits (Research Scope)

• Non-Mitogenic GH Fragment: AOD9604 is a fragment of human growth hormone that retains the lipolytic (fat-burning) and metabolic effects of GH without stimulating IGF-1 production or promoting growth. This makes it a unique research tool for studying metabolic regulation independent of the growth-promoting axis.

• Versatile Research Tool: Suitable for a wide range of studies, including:

  • Metabolic Disorders: Research into obesity, type 2 diabetes, metabolic syndrome, and lipid metabolism disorders.

  • Lipolysis & Fat Oxidation: Studies on fat breakdown, fatty acid oxidation, and energy metabolism.

  • Adipose Tissue Biology: Research into adipocyte function, fat cell metabolism, and adipose tissue regulation.

  • Glucose Metabolism: Studies on glucose homeostasis, insulin sensitivity, and glycemic control.

  • Aging Research: Investigation into age-related metabolic decline, fat accumulation, and metabolic health.

  • Endocrinology: Research into the structure-function relationships of growth hormone and its metabolic effects.

  • Inflammatory Research: Studies on the potential anti-inflammatory effects of AOD9604 in metabolic inflammation.

• Practical Formulation: The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both in vitro and in vivo experiments.

Research & Science

AOD9604 is a well-characterized fragment of human growth hormone that has been extensively studied for its metabolic effects, with a growing body of research supporting its applications in obesity and metabolic research.

• Mechanism of Action: AOD9604 is a 15-amino-acid peptide corresponding to the C-terminal region of human growth hormone (amino acids 177-191). Its mechanism of action includes:

  • Lipolysis Stimulation: AOD9604 stimulates lipolysis (fat breakdown) in adipocytes through activation of hormone-sensitive lipase (HSL), leading to the release of free fatty acids from adipose tissue.

  • Fatty Acid Oxidation: Promotes fatty acid oxidation, enhancing energy expenditure and fat utilization.

  • Metabolic Rate Enhancement: Increases resting metabolic rate and energy expenditure, contributing to reduced fat accumulation.

  • No IGF-1 Stimulation: Unlike full-length growth hormone, AOD9604 does not stimulate IGF-1 production, minimizing the risk of mitogenic and insulin resistance effects.

  • Anti-Inflammatory Effects: Some studies suggest potential anti-inflammatory effects, including modulation of pro-inflammatory cytokines.

  • Adipocyte Size Reduction: Reduces adipocyte size and fat accumulation in research models.

• Distinct from Full-Length Growth Hormone: The key advantage of AOD9604 is its separation of metabolic and growth-promoting effects:

  • Retains: Lipolytic, metabolic, and energy expenditure effects.

  • Does not produce: IGF-1 elevation, insulin resistance, mitogenic effects, or growth promotion.

• Lipolysis Research: Studies have demonstrated that AOD9604:

  • Stimulates lipolysis in adipocytes in vitro.

  • Reduces fat mass in animal models of obesity.

  • Increases metabolic rate and energy expenditure.

  • Decreases adipocyte size and fat accumulation.

• Metabolic Research: AOD9604 has been shown to:

  • Improve lipid profiles with reductions in triglycerides and LDL cholesterol.

  • Potentially improve insulin sensitivity without causing hyperglycemia.

  • Support metabolic health in models of diet-induced obesity.

• Obesity Research: As a peptide that mimics the lipolytic effects of GH without the growth-promoting effects, AOD9604 is a valuable tool for:

  • Studying the mechanisms of fat metabolism and adipose tissue regulation.

  • Investigating potential interventions for obesity and metabolic syndrome.

  • Understanding the structure-function relationships of growth hormone.

• Comparative Studies: AOD9604 is used in comparative studies with full-length growth hormone and other GH fragments to understand the specific roles of different domains of the GH molecule in metabolic regulation.

• Clinical Research Context: AOD9604 has been evaluated in clinical trials for obesity, demonstrating:

  • Significant reductions in body weight and fat mass.

  • Favorable safety and tolerability profiles.

  • No significant effects on blood glucose or IGF-1 levels.

• Focus on Genetic Variability: Research is exploring how genetic polymorphisms in lipid metabolism genes, adipocyte signaling pathways, and hormone-sensitive lipase may influence individual responses to AOD9604, providing insights for personalized metabolic interventions.