{"product_id":"yohimbinos-yohimbine-hydrochloride","title":"Yohimbinos (Yohimbine Hydrochloride)","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eYohimbinos\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a research compound from Driada Medical, containing \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eYohimbine Hydrochloride\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e. Yohimbine is an indole alkaloid derived from the bark of the \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003ePausinystalia yohimbe\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"\"\u003e tree, native to Central and West Africa, though it can also be produced synthetically\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/panoramafarmaceutico.com.br\/glossario\/yohimbina\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its chemical formula is C₂₁H₂₆N₂O₃·HCl, with a molecular weight of approximately 390.9 g\/mol\u003c\/span\u003e\u003ca href=\"https:\/\/www.drugfuture.com\/Pharmacopoeia\/BP2012\/data\/6484.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.acetherapeutics.com\/psychiatry\/yohimbine-hydrochloride-item-28.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It is a white to slightly yellowish, crystalline powder\u003c\/span\u003e\u003ca href=\"https:\/\/www.drugfuture.com\/Pharmacopoeia\/BP2012\/data\/6484.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe compound is recognized primarily as a potent and selective \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eα2-adrenergic receptor antagonist\u003c\/span\u003e\u003c\/strong\u003e\u003ca href=\"https:\/\/www.drugfuture.com\/Pharmacopoeia\/BP2012\/data\/6484.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/ebiz-newtest.merckmillipore.com\/SG\/en\/product\/sigma\/y3125\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This mechanism has positioned it as a standard tool for research into adrenergic signaling, metabolic regulation, and erectile function\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/panoramafarmaceutico.com.br\/glossario\/yohimbina\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe product is intended for \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003elaboratory research use only\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and features an integrated QR code on the packaging for detailed product verification.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProduct Name:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Yohimbinos (Yohimbine Hydrochloride)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eBrand:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Driada Medical\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eForm:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Solution for research applications\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCAS Number:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e 65-19-0\u003c\/span\u003e\u003ca href=\"https:\/\/www.drugfuture.com\/Pharmacopoeia\/BP2012\/data\/6484.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.acetherapeutics.com\/psychiatry\/yohimbine-hydrochloride-item-28.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Research Use Only.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch Applications \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eα2-Adrenergic Receptor Antagonist:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Yohimbine functions as a competitive antagonist at α2-adrenergic receptors\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. By blocking these presynaptic receptors, it inhibits the negative feedback mechanism that normally suppresses norepinephrine release, leading to increased synaptic levels of this neurotransmitter and enhanced sympathetic nervous system activity\u003c\/span\u003e\u003ca href=\"https:\/\/panoramafarmaceutico.com.br\/glossario\/yohimbina\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic \u0026amp; Lipolysis Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Due to its sympathomimetic effects, yohimbine is a compound of interest in research on energy metabolism and fat oxidation. It has been explored for its potential to promote lipolysis (fat breakdown) and as an adjuvant in weight loss research models, although these applications remain controversial\u003c\/span\u003e\u003ca href=\"https:\/\/panoramafarmaceutico.com.br\/glossario\/yohimbina\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.opss.org\/article\/yohimbe-and-yohimbine-dietary-supplement-products\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCurrent scientific evidence does not support its use for these purposes in a clinical context\u003c\/span\u003e\u003c\/strong\u003e\u003ca href=\"https:\/\/www.opss.org\/article\/yohimbe-and-yohimbine-dietary-supplement-products\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSexual Function Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Yohimbine's mechanism of action on α2-adrenergic receptors in the corpus cavernosum leads to sustained engorgement of penile tissue, making it a useful tool for studying the physiology of erectile function\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/panoramafarmaceutico.com.br\/glossario\/yohimbina\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It has been used as a reference compound in research for erectile dysfunction, particularly in models of neurogenic or vascular causes\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/panoramafarmaceutico.com.br\/glossario\/yohimbina\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeuroscience Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Yohimbine has significant effects on the central nervous system. It is used in research to study anxiety, stress responses, and the hypothalamic-pituitary-adrenal (HPA) axis, as it can induce anxiety-like behaviors and increase the release of stress hormones such as cortisol\u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It also interacts with serotonin (5-HT1A, 5-HT1B, 5-HT1D) and dopamine (D2, D3) receptors, albeit with lower affinity, making it relevant for receptor pharmacology studies\u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Scientific Background\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePharmacological Profile:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Yohimbine is a complex and promiscuous compound. While its primary action is α2-adrenergic antagonism, it also exhibits moderate affinity for serotonin receptors and some affinity for dopamine receptors\u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. At higher concentrations, it can act as an α1-agonist, leading to vasoconstriction and increased blood pressure, a dual action that complicates its effects\u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It can also bind to imidazoline I2 receptors, which are involved in blood pressure regulation\u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePharmacokinetics:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Yohimbine is rapidly absorbed following oral administration (absorption half-life ~10 min) and has a relatively short elimination half-life of approximately 30 minutes\u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. However, its oral bioavailability is highly variable, ranging from 10% to 90%, which is a critical consideration in pharmacokinetic studies\u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11641166\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSafety \u0026amp; Toxicology:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Yohimbine's therapeutic window is narrow. Common side effects in research models include insomnia, anxiety, palpitations, sweating, and hypertension\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.opss.org\/article\/yohimbe-and-yohimbine-dietary-supplement-products\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Overdose can cause severe hypotension, tachycardia, seizures, paralysis, and coma, and deaths from overdose have been reported\u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548703\/?report=reader\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It is also associated with a risk of drug interactions, particularly with other stimulants\u003c\/span\u003e\u003ca href=\"https:\/\/www.opss.org\/article\/yohimbe-and-yohimbine-dietary-supplement-products\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eRegulatory Context:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Dietary supplements containing yohimbe bark or yohimbine are banned in several countries, including Canada, Australia, the Netherlands, and the United Kingdom, due to potential health risks\u003c\/span\u003e\u003ca href=\"https:\/\/www.opss.org\/article\/yohimbe-and-yohimbine-dietary-supplement-products\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This regulatory environment underscores its status as a potent pharmacological tool requiring careful handling in research settings.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Driada","offers":[{"title":"Default Title","offer_id":58726488604997,"sku":null,"price":30.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/Driada-Yohimbinos.png?v=1785450606","url":"https:\/\/genetic-peps.shop\/products\/yohimbinos-yohimbine-hydrochloride","provider":"Genetic Peps","version":"1.0","type":"link"}