SS-31

About the Product

Genetic Labs SS-31 is a high-purity synthetic peptide (research grade) supplied in a vial containing 10mg of lyophilized (freeze-dried) powder. SS-31, also known as Elamipretide, is a novel mitochondrial-targeted peptide composed of alternating aromatic and basic amino acids (D-Arg-dimethylTyr-Lys-Phe-NH2). Its unique structure allows it to selectively accumulate in the inner mitochondrial membrane, where it exerts potent protective effects against oxidative stress and mitochondrial dysfunction.

Kit Contents:

• 1 Vial with 10mg SS-31 (Lyophilized Powder)

• 1 Vial with 3mL Bacteriostatic Water (Diluent)

For Laboratory Research Use Only. Not for human consumption.

Benefits (Research Scope)

• Mitochondrial-Targeted Peptide: SS-31 specifically targets the inner mitochondrial membrane, where it interacts with cardiolipin, a phospholipid essential for mitochondrial structure and function. This interaction stabilizes the mitochondrial membrane, prevents the formation of reactive oxygen species (ROS), and supports efficient energy (ATP) production.

• Versatile Research Tool: Suitable for a wide range of studies, including:

  • Mitochondrial Dysfunction: Research into aging-related mitochondrial decline, mitochondrial diseases, and disorders involving impaired energy metabolism.

  • Cardiovascular Research: Studies on cardiac ischemia-reperfusion injury, heart failure, and cardiomyopathy, where mitochondrial damage plays a key role.

  • Neurodegenerative Disorders: Investigation into Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS), all of which involve mitochondrial dysfunction.

  • Renal Research: Studies on acute kidney injury, chronic kidney disease, and contrast-induced nephropathy.

  • Metabolic Disorders: Research into insulin resistance, obesity, and type 2 diabetes, where mitochondrial dysfunction contributes to disease progression.

  • Skeletal Muscle Research: Studies on sarcopenia, muscular dystrophy, and age-related muscle weakness.

• Practical Formulation: The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both in vitro and in vivo experiments.

Research & Science

SS-31 (Elamipretide) is one of the most extensively studied mitochondrial-targeted therapeutic peptides, with a robust body of preclinical and clinical research supporting its mechanism and broad therapeutic potential.

• Mechanism of Action: SS-31 is a cationic, aromatic peptide that binds selectively to cardiolipin in the inner mitochondrial membrane. This binding:

  • Stabilizes the mitochondrial membrane structure and prevents the disruption of cristae architecture.

  • Inhibits the formation of reactive oxygen species (ROS) without interfering with beneficial mitochondrial signaling.

  • Restores mitochondrial bioenergetics by facilitating the transfer of electrons between complexes III and IV of the electron transport chain.

  • Prevents cytochrome c release and downstream apoptosis pathways.

• Clinical Validation: SS-31 has advanced into multiple clinical trials for various indications, including:

  • Heart Failure: Demonstrated improvements in cardiac function and reduced biomarkers of cardiac stress.

  • Barth Syndrome: Showed improvements in exercise capacity and cardiac function in this rare mitochondrial disorder.

  • Leber's Hereditary Optic Neuropathy (LHON): Evaluated for visual function improvement in mitochondrial optic neuropathy.

  • Age-Related Macular Degeneration (AMD): Investigated for its potential to protect retinal cells from oxidative damage.

• Neuroprotective Research: Studies have demonstrated that SS-31 significantly reduces neuronal cell death, preserves mitochondrial function, and improves cognitive outcomes in animal models of neurodegenerative diseases.

• Renoprotective Research: SS-31 has shown efficacy in reducing oxidative damage and preserving renal function in models of acute kidney injury and diabetic nephropathy.

• Aging & Longevity Research: As mitochondrial dysfunction is a hallmark of aging, SS-31 is being investigated as a potential therapeutic to counteract age-related decline in cellular energy production, muscle function, and metabolic health.

• Focus on Genetic Variability: Current research is exploring how genetic variations in mitochondrial DNA (mtDNA) and nuclear genes involved in mitochondrial function may influence individual responses to SS-31, paving the way for personalized mitochondrial medicine.