{"product_id":"slu-pp-332","title":"SLU-PP-332","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGenetic Labs SLU-PP-332\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a high-purity synthetic compound (research grade) supplied in a vial containing 5mg of lyophilized (freeze-dried) powder. SLU-PP-332 is a novel, non-hormonal, small molecule that functions as a potent pan-agonist of the \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eestrogen-related receptors (ERRs)\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e , specifically targeting ERRα, ERRβ, and ERRγ. These receptors are key regulators of mitochondrial biogenesis, oxidative metabolism, and energy homeostasis. SLU-PP-332 has emerged as a groundbreaking research tool for studying metabolic adaptation, exercise mimetics, and mitochondrial function.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eKit Contents:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e1 Vial with 5mg SLU-PP-332 (Lyophilized Powder)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e1 Vial with Bacteriostatic Water (Diluent)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Laboratory Research Use Only. Not for human consumption.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eBenefits (Research Scope)\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePan-ERR Agonist:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e SLU-PP-332 is the first-in-class small molecule that selectively and potently activates all three ERR isoforms (ERRα, ERRβ, and ERRγ). This unique activity allows researchers to study the coordinated activation of the entire ERR transcriptional network, which controls mitochondrial function, fatty acid oxidation, and glucose metabolism.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eExercise Mimetic Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e SLU-PP-332 has been shown to induce a transcriptional and metabolic profile similar to endurance exercise, including increased oxidative capacity, enhanced fatty acid oxidation, and improved metabolic flexibility. This makes it a powerful tool for studying exercise mimetics and metabolic adaptations without physical training.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eVersatile Research Tool:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Suitable for a wide range of studies, including:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Disorders:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into obesity, type 2 diabetes, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMitochondrial Biology:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on mitochondrial biogenesis, oxidative phosphorylation, and mitochondrial dysfunction.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMuscle Physiology:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into skeletal muscle adaptation, endurance performance, and muscle wasting conditions (sarcopenia, cachexia).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCardiovascular Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on cardiac metabolism, heart failure, and ischemic heart disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAging \u0026amp; Longevity:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Investigation into age-related metabolic decline and mitochondrial dysfunction.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCancer Metabolism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into metabolic reprogramming in cancer cells and potential therapeutic targets.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePractical Formulation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003ein vitro\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"\"\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003ein vivo\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"\"\u003e experiments.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Science\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eSLU-PP-332 is a revolutionary small molecule that has garnered significant attention in the scientific community for its ability to mimic the beneficial effects of exercise at the molecular level.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMechanism of Action:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e SLU-PP-332 binds to the ligand-binding domain of all three ERR isoforms, inducing a conformational change that recruits coactivators (such as PGC-1α) and activates transcription of target genes. These target genes include those involved in:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMitochondrial biogenesis\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (e.g., PGC-1α, NRF1, TFAM)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFatty acid oxidation\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (e.g., CPT1B, MCAD, PDK4)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eOxidative phosphorylation\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (e.g., subunits of complexes I-V)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGlucose metabolism\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (e.g., GLUT4, pyruvate dehydrogenase)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAntioxidant defense\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (e.g., SOD2, catalase)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eExercise-Mimetic Effects:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Preclinical studies have demonstrated that SLU-PP-332:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIncreases oxygen consumption and metabolic rate\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e in vivo.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEnhances fatty acid oxidation\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and reduces lipid accumulation in skeletal muscle and liver.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eImproves glucose tolerance and insulin sensitivity\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e in diet-induced obesity models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIncreases endurance capacity\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e in animal models without physical training.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePrevents weight gain\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and reduces adiposity in high-fat diet-fed animals.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Disease Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e SLU-PP-332 has shown remarkable efficacy in reversing metabolic dysfunction in animal models of obesity and type 2 diabetes, including significant reductions in fasting glucose, insulin, and triglycerides, as well as improvement in hepatic steatosis.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMuscle Wasting Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies have demonstrated that SLU-PP-332 can preserve muscle mass and function in models of sarcopenia and cachexia, offering potential for research into age-related and disease-related muscle loss.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCardioprotective Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e SLU-PP-332 has been investigated for its ability to improve cardiac function, enhance cardiac mitochondrial respiration, and protect against ischemic injury in models of heart failure.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAging \u0026amp; Longevity:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e As ERR activity declines with age, SLU-PP-332 is being studied as a potential intervention to counteract age-related metabolic decline and improve healthspan.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFocus on Genetic Variability:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Current research is exploring how genetic variations in ERR target genes, PGC-1α, and other metabolic pathway genes may influence individual responses to SLU-PP-332, paving the way for personalized metabolic interventions.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eImportant Note on Kit Contents\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003ePlease verify the kit contents as listed in the image:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e1 x Vial SLU-PP-332 (Lyophilized Powder) 5mg\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e1 x Vial Bacteriostatic Water (Diluent) 3mL\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003e(Note: The text in the image appears to have a typo. It should read \"Bacteriostatic Water\" as per standard practice.)\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Genetic Labs","offers":[{"title":"Default Title","offer_id":58672532685125,"sku":null,"price":74.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/GeneticLabs-SLU-PP-332_5mg.jpg?v=1784936869","url":"https:\/\/genetic-peps.shop\/products\/slu-pp-332","provider":"Genetic Peps","version":"1.0","type":"link"}