{"product_id":"semaglutide","title":"Semaglutide","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGenetic Labs Semaglutide\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a high-purity synthetic peptide (research grade) supplied in a vial containing 5mg of lyophilized (freeze-dried) powder. Semaglutide is a synthetic analog of the human glucagon-like peptide-1 (GLP-1) hormone, engineered for enhanced stability and extended duration of action. It functions as a potent and selective GLP-1 receptor agonist, making it a valuable tool for research in metabolism, endocrinology, and neurobiology.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eKit Contents:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e1 Vial with 5mg Semaglutide (Lyophilized Powder)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e1 Vial with Bacteriostatic Water (Diluent)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Laboratory Research Use Only. Not for human consumption.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eBenefits (Research Scope)\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGLP-1 Receptor Agonist:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Semaglutide selectively binds to and activates the GLP-1 receptor (GLP-1R), a key regulator of glucose homeostasis, insulin secretion, appetite, and gastric emptying. Its prolonged half-life makes it particularly suitable for studying sustained GLP-1 receptor activation.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eVersatile Research Tool:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Suitable for a wide range of studies, including:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Disorders:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into type 2 diabetes, obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD).\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAppetite \u0026amp; Energy Balance:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on hypothalamic regulation of food intake, satiety signaling, and body weight control.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeuroendocrinology:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Investigation into the role of GLP-1 in the central nervous system, including neuroprotection, cognitive function, and reward pathways.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCardiovascular Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on the cardioprotective effects of GLP-1 receptor agonists, including blood pressure regulation, endothelial function, and cardiac metabolism.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGastrointestinal Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into gastric motility, gastric emptying, and enteric nervous system function.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eRenal Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on the protective effects of GLP-1 agonists on kidney function in models of diabetic nephropathy.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePractical Formulation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003ein vitro\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"\"\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003ein vivo\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"\"\u003e experiments.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Science\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eSemaglutide is one of the most extensively studied GLP-1 receptor agonists, with a robust body of preclinical and clinical research supporting its mechanism and broad therapeutic potential.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMechanism of Action:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Semaglutide is a 31-amino-acid peptide analog of human GLP-1. It binds to the GLP-1 receptor (GLP-1R) on pancreatic beta cells, activating the cAMP-dependent signaling pathway, which leads to:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGlucose-dependent insulin secretion:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Insulin release is stimulated only when blood glucose levels are elevated, minimizing the risk of hypoglycemia.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSuppression of glucagon secretion:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Reduces hepatic glucose production.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSlowing of gastric emptying:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Delays nutrient absorption, contributing to postprandial glucose control.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAppetite suppression:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Acts on hypothalamic GLP-1 receptors to reduce food intake and promote satiety.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eWeight loss:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Promotes sustained weight reduction through a combination of central and peripheral mechanisms.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eExtended Duration:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Semaglutide's structure includes a fatty acid side chain (C18) that facilitates albumin binding, resulting in a prolonged half-life of approximately 7 days, making it suitable for once-weekly dosing in clinical studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Preclinical studies have demonstrated that semaglutide:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSignificantly reduces body weight\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and adiposity in diet-induced obesity models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eImproves glycemic control\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and insulin sensitivity.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eReduces hepatic steatosis\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and liver inflammation in NAFLD models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eImproves lipid profiles\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e with reductions in triglycerides and LDL cholesterol.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCardiovascular Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Semaglutide has been shown to improve cardiovascular outcomes in clinical trials, including reduced risk of major adverse cardiovascular events (MACE), making it a key compound for research into cardiometabolic health.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeuroprotective Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Emerging research is exploring semaglutide's potential in neurodegenerative diseases. GLP-1 receptors are expressed in the brain, and studies have shown that semaglutide may reduce neuroinflammation, improve cognitive function, and protect against neuronal death in models of Alzheimer's disease and Parkinson's disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eRenal Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Semaglutide has demonstrated reno-protective effects, including reduced albuminuria and preservation of kidney function in models of diabetic nephropathy.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFocus on Genetic Variability:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Current research is investigating how genetic polymorphisms in the GLP-1 receptor gene (GLP1R) and other metabolic pathway genes may influence individual responses to semaglutide, providing insights for personalized metabolic interventions.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Genetic Labs","offers":[{"title":"Default Title","offer_id":58672593109317,"sku":null,"price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/GeneticLabs-Semaglutide_5mg.jpg?v=1784937053","url":"https:\/\/genetic-peps.shop\/products\/semaglutide","provider":"Genetic Peps","version":"1.0","type":"link"}