{"product_id":"provironus-mesterolone","title":"Provironus (Mesterolone)","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProvironus\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a research compound from Driada Medical, containing \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMesterolone\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e. Mesterolone is a synthetic, orally active androgen and a derivative of dihydrotestosterone (DHT)\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Optimizing_Mesterolone_dosage_to_minimize_adverse_effects_in_research.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its chemical formula is C₂₀H₃₂O₂, with a molecular weight of 304.47 g\/mol\u003c\/span\u003e\u003ca href=\"https:\/\/drugs.ncats.io\/drug\/mesterolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe compound is characterized by a \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e1α-methyl group\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e on the DHT backbone. This structural modification prevents the metabolism of the steroid to estrogen (aromatization), distinguishing it from testosterone and its derivatives\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This feature, combined with its oral bioavailability and relatively good hepatic tolerability, makes it a valuable research tool for studying androgen receptor (AR) signaling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe product is intended for \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003elaboratory research use only\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and features an integrated QR code on the packaging for detailed product verification.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProduct Name:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Provironus (Mesterolone)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eBrand:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Driada Medical\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eForm:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Solution for research applications\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCAS Number:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e 1424-00-6\u003c\/span\u003e\u003ca href=\"https:\/\/drugs.ncats.io\/drug\/mesterolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Research Use Only.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch Applications \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAndrogen Receptor Agonist:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Mesterolone functions as an agonist at the androgen receptor (AR)\u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Optimizing_Mesterolone_dosage_to_minimize_adverse_effects_in_research.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its relative binding affinity (RBA) is approximately \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e25\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e when compared to the synthetic androgen methyltrienolone (MT, RBA=100) in rat prostate tissue\u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Assessing_the_relative_binding_affinity_of_Mesterolone_to_androgen_receptors.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. For reference, DHT has an RBA of 46 in the same assay\u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Assessing_the_relative_binding_affinity_of_Mesterolone_to_androgen_receptors.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNon-Aromatizable Androgen:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Due to its 1α-methyl group, mesterolone is not a substrate for the aromatase enzyme and therefore does not convert to estrogen\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This makes it a valuable tool for studying pure androgenic effects without the confounding variables of estrogenic activity\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHigh SHBG Affinity:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Mesterolone exhibits an exceptionally high affinity for sex hormone-binding globulin (SHBG), approximately \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e4 times that of DHT\u003c\/span\u003e\u003c\/strong\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Assessing_the_relative_binding_affinity_of_Mesterolone_to_androgen_receptors.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. In research models where SHBG expression is relevant, this property can be used to study the displacement of endogenous testosterone and consequent alterations in the free fraction of the hormone\u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Assessing_the_relative_binding_affinity_of_Mesterolone_to_androgen_receptors.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Optimizing_Mesterolone_dosage_to_minimize_adverse_effects_in_research.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSteroidogenesis Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Recent research has shown that mesterolone can interfere with adrenal steroidogenesis. Studies in H295R cells demonstrate that mesterolone increases mineralocorticoid production (aldosterone and 11-deoxycorticosterone) while decreasing adrenal androgen production, suggesting an indirect inhibition of CYP17A1 function\u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006295219304800?via%3Dihub\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This positions the compound as a relevant tool for studying steroidogenic disturbances and their link to cardiovascular effects\u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006295219304800?via%3Dihub\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHormonal Regulation Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Unlike many other androgens, mesterolone at therapeutic doses does not significantly suppress the release of gonadotropins (LH and FSH) in healthy men, likely due to its low central activity\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This profile allows researchers to study its effects without the complete suppression of the hypothalamic-pituitary-gonadal (HPG) axis often seen with other AAS\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePharmacokinetic Studies:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Mesterolone is rapidly and almost completely absorbed after oral administration in the 25-100 mg dose range, reaching peak serum concentrations in approximately 1.6 hours\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its absolute bioavailability is around \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e3%\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e due to extensive first-pass metabolism\u003c\/span\u003e\u003ca href=\"https:\/\/www.bayer.com\/sites\/default\/files\/2024-02\/20231117-rcm-proviron-rec20624.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It is highly protein-bound (98%), with 58% binding to SHBG and 40% to albumin\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. The serum elimination half-life is \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e12-13 hours\u003c\/span\u003e\u003c\/strong\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Scientific Background\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eChemical Background:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Mesterolone is a DHT derivative with a methyl group at the C-1 position. Its structural features confer oral bioavailability while the lack of 17α-alkylation contributes to a better hepatic tolerability profile compared to other orally active androgens\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eClinical Context:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Mesterolone (Proviron) has been clinically indicated for the treatment of conditions related to androgen deficiency in men, including hypogonadism, infertility, and disturbances of libido and potency\u003c\/span\u003e\u003ca href=\"https:\/\/www.bayer.com\/sites\/default\/files\/2024-02\/20231117-rcm-proviron-rec20624.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.bayer.com\/sites\/default\/files\/proviron-smpc-nov-2023.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAndrogen Receptor Binding Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The relative binding affinity (RBA) of mesterolone has been characterized in competitive binding assays. Data indicates an RBA of \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e25\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (vs. methyltrienolone) and \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e~400\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (vs. DHT in SHBG binding)\u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Assessing_the_relative_binding_affinity_of_Mesterolone_to_androgen_receptors.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This places its AR affinity between testosterone and DHT, but its SHBG affinity is markedly higher\u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Assessing_the_relative_binding_affinity_of_Mesterolone_to_androgen_receptors.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAdrenal Steroidogenesis Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e A study profiling the effects of various AAS on adrenal steroidogenesis identified mesterolone as a compound that increases mineralocorticoid biosynthesis (aldosterone and 11-deoxycorticosterone) while decreasing adrenal androgen production in H295R cells\u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006295219304800?via%3Dihub\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. The mechanism did not involve direct CYP17A1 inhibition or altered gene expression of key steroidogenic enzymes (3β-HSD2, CYP17A1, CYP21A2, CYP11B1, CYP11B2), suggesting an indirect effect potentially involving post-translational modification or impaired protein stability\u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006295219304800?via%3Dihub\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This has been linked to the potential for promoting hypertension and cardiovascular diseases through mineralocorticoid excess\u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006295219304800?via%3Dihub\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eDrug Metabolism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Mesterolone is rapidly metabolized to 1α-methyl-androsterone (55-70% of metabolites) and 1α-methyl-5α-androstane-3α,17β-diol (~3%)\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. No metabolic conversion to estrogens or corticoids has been observed\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Approximately 80% of the dose is excreted in urine as metabolites and 13% in feces\u003c\/span\u003e\u003ca href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/48881\/FT_48881.pdf#2#2\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGenetic Variability Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e While direct pharmacogenomic studies on mesterolone are limited, its high affinity for SHBG suggests that polymorphisms in the SHBG gene (which are common and associated with SHBG levels) may influence its biological activity by affecting the free fraction of the compound.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Driada","offers":[{"title":"Default Title","offer_id":58726491128133,"sku":null,"price":35.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/Driada-Provironus.jpg?v=1785450678","url":"https:\/\/genetic-peps.shop\/products\/provironus-mesterolone","provider":"Genetic Peps","version":"1.0","type":"link"}