{"product_id":"nolvados-tamoxifen-citrate","title":"Nolvados (Tamoxifen Citrate)","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNolvados\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a research compound from Driada Medical, containing \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eTamoxifen Citrate\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e. Tamoxifen Citrate is a nonsteroidal, orally active agent classified as a \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eselective estrogen receptor modulator (SERM)\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/017970s054lbl.pdf#10#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/clinicaltrials.eu\/drug\/tamoxifen-citrate\/?cst\u0026amp;query-5-page=1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its chemical formula is C₃₂H₃₇NO₈, with a molecular weight of 563.64 g\/mol \u003c\/span\u003e\u003ca href=\"https:\/\/www.peptidedb.com\/database\/Tamoxifen-Citrate.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"http:\/\/file.medchemexpress.com\/batch_PDF\/HY-13757R\/Tamoxifen-Citrate-Standard-DataSheet-MedChemExpress.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe compound functions by competitively binding to estrogen receptors in target tissues \u003c\/span\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/017970s054lbl.pdf#10#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. In breast tissue, it acts as a potent antagonist, blocking estrogen from stimulating cell growth \u003c\/span\u003e\u003ca href=\"https:\/\/clinicaltrials.eu\/drug\/tamoxifen-citrate\/?cst\u0026amp;query-5-page=1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This anti-estrogenic profile is central to its research applications.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProduct Name:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Nolvados (Tamoxifen Citrate)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eBrand:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Driada Medical\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eForm:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Solution for research applications\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCAS Number:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e 54965-24-1 \u003c\/span\u003e\u003ca href=\"https:\/\/www.peptidedb.com\/database\/Tamoxifen-Citrate.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"http:\/\/file.medchemexpress.com\/batch_PDF\/HY-13757R\/Tamoxifen-Citrate-Standard-DataSheet-MedChemExpress.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Research Use Only.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch Applications \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSelective Estrogen Receptor Modulator (SERM):\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Tamoxifen is a benchmark compound for studying estrogen receptor (ER) biology due to its tissue-specific effects \u003c\/span\u003e\u003ca href=\"https:\/\/www.targetmol.cn\/compound\/tamoxifen%20citrate\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It acts as an antagonist in breast tissue, blocking estrogen-driven proliferation, but can exhibit agonist activity in other tissues such as bone and the endometrium \u003c\/span\u003e\u003ca href=\"https:\/\/www.targetmol.cn\/compound\/tamoxifen%20citrate\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.scbt.com\/p\/tamoxifen-citrate-54965-24-1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This complex pharmacology is valuable for investigating receptor dynamics and tissue-specific signaling.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCancer Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e As a model anti-estrogen, tamoxifen is widely used to study hormone-responsive cancers, particularly ER-positive breast cancer models. Research includes investigating mechanisms of acquired resistance and combination therapies \u003c\/span\u003e\u003ca href=\"https:\/\/clinicaltrials.eu\/drug\/tamoxifen-citrate\/?cst\u0026amp;query-5-page=1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGene Regulation \u0026amp; Apoptosis:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Tamoxifen is a potent activator of the Hsp90 molecular chaperone ATPase and can induce autophagy and apoptosis, making it relevant for studying cell death and stress response pathways \u003c\/span\u003e\u003ca href=\"http:\/\/file.medchemexpress.com\/batch_PDF\/HY-13757R\/Tamoxifen-Citrate-Standard-DataSheet-MedChemExpress.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.targetmol.cn\/compound\/tamoxifen%20citrate\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eTransgenic Model Generation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Tamoxifen is a critical tool for generating inducible gene knockout models. When used with CreER(T2) transgenic mice, tamoxifen administration enables temporal control of gene deletion, a cornerstone of modern functional genetics research \u003c\/span\u003e\u003ca href=\"https:\/\/www.peptidedb.com\/database\/Tamoxifen-Citrate.html\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"http:\/\/file.medchemexpress.com\/batch_PDF\/HY-13757R\/Tamoxifen-Citrate-Standard-DataSheet-MedChemExpress.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.targetmol.cn\/compound\/tamoxifen%20citrate\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHsp90 \u0026amp; Kinase Inhibition:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Beyond its nuclear receptor activity, tamoxifen is a known inhibitor of protein kinase C (PKC) and an activator of the GPR30 receptor, demonstrating its utility in studying non-genomic signaling pathways \u003c\/span\u003e\u003ca href=\"https:\/\/www.scbt.com\/p\/tamoxifen-citrate-54965-24-1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Scientific Background\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMechanism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Tamoxifen competes with estradiol for estrogen receptor binding \u003c\/span\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/017970s054lbl.pdf#10#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2002\/21109lbl,17970s50lbl.pdf#9#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. In breast tissue, the tamoxifen-receptor complex recruits co-repressors, halting the transcription of estrogen-responsive genes required for cell proliferation \u003c\/span\u003e\u003ca href=\"https:\/\/www.scbt.com\/p\/tamoxifen-citrate-54965-24-1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The compound is extensively metabolized, primarily by cytochrome P450 enzymes (CYP3A4, CYP2D6), to active metabolites including N-desmethyl tamoxifen and 4-hydroxytamoxifen \u003c\/span\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/017970s054lbl.pdf#10#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2005\/17970s053lbl.pdf#7#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This metabolic profile is a key consideration in pharmacogenomic research.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePharmacokinetics:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Following oral administration, tamoxifen has a terminal elimination half-life of approximately 5-7 days, with its major metabolite having a half-life of about 14 days \u003c\/span\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/017970s054lbl.pdf#10#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2005\/17970s053lbl.pdf#7#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2002\/21109lbl,17970s50lbl.pdf#9#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Steady-state concentrations are achieved after several weeks.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Driada","offers":[{"title":"Default Title","offer_id":58726443778373,"sku":null,"price":35.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/Driada-Nolvados.jpg?v=1785449917","url":"https:\/\/genetic-peps.shop\/products\/nolvados-tamoxifen-citrate","provider":"Genetic Peps","version":"1.0","type":"link"}