{"product_id":"mots-c","title":"MOTS-C","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGenetic Labs MOTS-C\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a high-purity synthetic peptide (research grade) supplied in a vial containing 10mg of lyophilized (freeze-dried) powder. MOTS-C is a mitochondrial-derived peptide (MDP) encoded by a short open reading frame within the mitochondrial genome (specifically the 12S rRNA region). Comprising 16 amino acids, MOTS-C is a recently discovered bioactive peptide that acts as a mitochondrial signaling molecule, regulating cellular metabolism and energy homeostasis. It is particularly notable for its ability to modulate glucose and lipid metabolism, making it a valuable tool for research into metabolic disorders, aging, and exercise physiology.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eKit Contents:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e1 Vial with 10mg MOTS-C (Lyophilized Powder)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003e1 Vial with 3mL Bacteriostatic Water (Diluent)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Laboratory Research Use Only. Not for human consumption.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eBenefits (Research Scope)\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMitochondrial-Derived Peptide:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e MOTS-C is one of the first identified mitochondrial-encoded peptides with hormone-like activity. It acts as a systemic signaling molecule that communicates mitochondrial status to the rest of the cell and body, regulating adaptive metabolic responses.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eVersatile Research Tool:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Suitable for a wide range of studies, including:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Disorders:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into type 2 diabetes, insulin resistance, obesity, and metabolic syndrome.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAging \u0026amp; Longevity:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on age-related metabolic decline, mitochondrial dysfunction, and the role of mitochondrial peptides in healthspan and lifespan.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eExercise Physiology:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into skeletal muscle adaptation, endurance capacity, and exercise mimetics.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGlucose \u0026amp; Lipid Metabolism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on insulin sensitivity, glucose uptake, fatty acid oxidation, and lipid profiles.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeuroprotection:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Investigation into neuroprotective effects in models of neurodegeneration and cognitive decline.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCardiovascular Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Studies on cardiac metabolism, endothelial function, and cardiovascular protection.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eInflammatory Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into the anti-inflammatory effects of mitochondrial peptides in various disease models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePractical Formulation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003ein vitro\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"\"\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003ein vivo\u003c\/span\u003e\u003c\/em\u003e\u003cspan class=\"\"\u003e experiments.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Science\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eMOTS-C represents a paradigm shift in our understanding of mitochondrial biology, revealing that mitochondria are not just energy-producing organelles but also endocrine organs that produce bioactive peptides with systemic effects.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMechanism of Action:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e MOTS-C is a 16-amino-acid peptide (MRWQEMGYIFYPRKLR) that functions as a mitochondrial signaling molecule. Its mechanism of action includes:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAMPK Activation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e MOTS-C activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, promoting glucose uptake and fatty acid oxidation.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGLUT4 Translocation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Enhances translocation of GLUT4 glucose transporters to the cell membrane, facilitating glucose uptake into skeletal muscle and adipose tissue.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eInsulin Sensitivity:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Improves insulin sensitivity by reducing insulin resistance in peripheral tissues.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMitochondrial Biogenesis:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Promotes mitochondrial biogenesis and function, enhancing oxidative capacity and energy production.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAnti-Inflammatory Effects:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Modulates inflammatory pathways, reducing pro-inflammatory cytokine production.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Preclinical studies have demonstrated that MOTS-C:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eImproves glucose tolerance\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and insulin sensitivity in diet-induced obesity and aged mouse models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eReduces adiposity\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and prevents weight gain in high-fat diet-fed animals.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIncreases endurance capacity\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and exercise performance in animal models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEnhances metabolic flexibility\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e by promoting fatty acid oxidation during fasting and glucose utilization during feeding.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eReverses age-related insulin resistance\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, suggesting a role in combating metabolic decline associated with aging.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAging \u0026amp; Longevity Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e MOTS-C has been shown to improve metabolic parameters in aged mice, suggesting its potential as a therapeutic target for age-related metabolic disorders. Studies have demonstrated that MOTS-C levels decline with age, and supplementation can partially restore youthful metabolic function.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eExercise Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e MOTS-C has been identified as a key mediator of the beneficial effects of exercise. It is upregulated in response to exercise and contributes to improved metabolic health and enhanced physical performance.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeuroprotective Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Emerging research suggests that MOTS-C may have neuroprotective effects, potentially reducing neuroinflammation, improving mitochondrial function in neurons, and protecting against cognitive decline in models of neurodegenerative diseases.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFocus on Genetic Variability:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Current research is exploring how genetic variations in the mitochondrial genome (specifically in the region encoding MOTS-C) and nuclear genes involved in its signaling pathway may influence individual responses to MOTS-C, opening avenues for personalized metabolic and aging interventions.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eImportant Note on Kit Contents\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003ePlease verify the kit contents as listed in the image:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e1 x Vial MOTS-C (Lyophilized Powder) 10mg\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e1 x Vial Bacteriostatic Water (Diluent) 3mL\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e \u003c\/span\u003e\u003cem\u003e\u003cspan class=\"\"\u003e(Note: The text in the image appears to have a typo. It should read \"Bacteriostatic Water\" as per standard practice.)\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Genetic Labs","offers":[{"title":"Default Title","offer_id":58672597696837,"sku":null,"price":44.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/GeneticLabs-MOTS-C_10mg.jpg?v=1784937527","url":"https:\/\/genetic-peps.shop\/products\/mots-c","provider":"Genetic Peps","version":"1.0","type":"link"}