MOTS-C

About the Product

Genetic Labs MOTS-C is a high-purity synthetic peptide (research grade) supplied in a vial containing 10mg of lyophilized (freeze-dried) powder. MOTS-C is a mitochondrial-derived peptide (MDP) encoded by a short open reading frame within the mitochondrial genome (specifically the 12S rRNA region). Comprising 16 amino acids, MOTS-C is a recently discovered bioactive peptide that acts as a mitochondrial signaling molecule, regulating cellular metabolism and energy homeostasis. It is particularly notable for its ability to modulate glucose and lipid metabolism, making it a valuable tool for research into metabolic disorders, aging, and exercise physiology.

Kit Contents:

• 1 Vial with 10mg MOTS-C (Lyophilized Powder)

• 1 Vial with 3mL Bacteriostatic Water (Diluent)

For Laboratory Research Use Only. Not for human consumption.

Benefits (Research Scope)

• Mitochondrial-Derived Peptide: MOTS-C is one of the first identified mitochondrial-encoded peptides with hormone-like activity. It acts as a systemic signaling molecule that communicates mitochondrial status to the rest of the cell and body, regulating adaptive metabolic responses.

• Versatile Research Tool: Suitable for a wide range of studies, including:

  • Metabolic Disorders: Research into type 2 diabetes, insulin resistance, obesity, and metabolic syndrome.

  • Aging & Longevity: Studies on age-related metabolic decline, mitochondrial dysfunction, and the role of mitochondrial peptides in healthspan and lifespan.

  • Exercise Physiology: Research into skeletal muscle adaptation, endurance capacity, and exercise mimetics.

  • Glucose & Lipid Metabolism: Studies on insulin sensitivity, glucose uptake, fatty acid oxidation, and lipid profiles.

  • Neuroprotection: Investigation into neuroprotective effects in models of neurodegeneration and cognitive decline.

  • Cardiovascular Research: Studies on cardiac metabolism, endothelial function, and cardiovascular protection.

  • Inflammatory Research: Research into the anti-inflammatory effects of mitochondrial peptides in various disease models.

• Practical Formulation: The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both in vitro and in vivo experiments.

Research & Science

MOTS-C represents a paradigm shift in our understanding of mitochondrial biology, revealing that mitochondria are not just energy-producing organelles but also endocrine organs that produce bioactive peptides with systemic effects.

• Mechanism of Action: MOTS-C is a 16-amino-acid peptide (MRWQEMGYIFYPRKLR) that functions as a mitochondrial signaling molecule. Its mechanism of action includes:

  • AMPK Activation: MOTS-C activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, promoting glucose uptake and fatty acid oxidation.

  • GLUT4 Translocation: Enhances translocation of GLUT4 glucose transporters to the cell membrane, facilitating glucose uptake into skeletal muscle and adipose tissue.

  • Insulin Sensitivity: Improves insulin sensitivity by reducing insulin resistance in peripheral tissues.

  • Mitochondrial Biogenesis: Promotes mitochondrial biogenesis and function, enhancing oxidative capacity and energy production.

  • Anti-Inflammatory Effects: Modulates inflammatory pathways, reducing pro-inflammatory cytokine production.

• Metabolic Research: Preclinical studies have demonstrated that MOTS-C:

  • Improves glucose tolerance and insulin sensitivity in diet-induced obesity and aged mouse models.

  • Reduces adiposity and prevents weight gain in high-fat diet-fed animals.

  • Increases endurance capacity and exercise performance in animal models.

  • Enhances metabolic flexibility by promoting fatty acid oxidation during fasting and glucose utilization during feeding.

  • Reverses age-related insulin resistance, suggesting a role in combating metabolic decline associated with aging.

• Aging & Longevity Research: MOTS-C has been shown to improve metabolic parameters in aged mice, suggesting its potential as a therapeutic target for age-related metabolic disorders. Studies have demonstrated that MOTS-C levels decline with age, and supplementation can partially restore youthful metabolic function.

• Exercise Research: MOTS-C has been identified as a key mediator of the beneficial effects of exercise. It is upregulated in response to exercise and contributes to improved metabolic health and enhanced physical performance.

• Neuroprotective Research: Emerging research suggests that MOTS-C may have neuroprotective effects, potentially reducing neuroinflammation, improving mitochondrial function in neurons, and protecting against cognitive decline in models of neurodegenerative diseases.

• Focus on Genetic Variability: Current research is exploring how genetic variations in the mitochondrial genome (specifically in the region encoding MOTS-C) and nuclear genes involved in its signaling pathway may influence individual responses to MOTS-C, opening avenues for personalized metabolic and aging interventions.

Important Note on Kit Contents

Please verify the kit contents as listed in the image:

• 1 x Vial MOTS-C (Lyophilized Powder) 10mg

• 1 x Vial Bacteriostatic Water (Diluent) 3mL (Note: The text in the image appears to have a typo. It should read "Bacteriostatic Water" as per standard practice.)