A black box of Generic Ipamorelin 10 MG for laboratory research use only, standing on a white lab counter with pipettes, bottles, and other lab equipment blurred in the background.

Ipamorelin

€38,00
€38,00
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A black box of Generic Ipamorelin 10 MG for laboratory research use only, standing on a white lab counter with pipettes, bottles, and other lab equipment blurred in the background.
  • A black box of Generic Ipamorelin 10 MG for laboratory research use only, standing on a white lab counter with pipettes, bottles, and other lab equipment blurred in the background.
  • A black box of Generic Ipamorelin 10 MG for laboratory research use only, standing on a white lab counter with pipettes, bottles, and other lab equipment blurred in the background.
Ipamorelin

Ipamorelin

€38,00
€38,00

About the Product

Genetic Labs Ipamorelin is a high-purity synthetic peptide (research grade) supplied in a vial containing 10mg of lyophilized (freeze-dried) powder. Ipamorelin is a synthetic pentapeptide (consisting of 5 amino acids) that functions as a potent and selective growth hormone secretagogue. It belongs to the class of growth hormone-releasing peptides (GHRPs) and acts as an agonist at the ghrelin receptor (GHS-R1a), stimulating the release of growth hormone (GH) from the pituitary gland. Unlike other GHRPs, Ipamorelin is highly selective for GH release with minimal effect on other hormones such as cortisol, prolactin, or acetylcholine, making it a valuable research tool for endocrinology and metabolic studies.

Kit Contents:

  • 1 Vial with 10mg Ipamorelin (Lyophilized Powder)

  • 1 Vial with 3mL Bacteriostatic Water (Diluent)

For Laboratory Research Use Only. Not for human consumption.

Benefits (Research Scope)

  • Growth Hormone Secretagogue: Ipamorelin stimulates the release of endogenous growth hormone (GH) from the pituitary gland by binding to and activating the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor. Its high selectivity makes it ideal for studying the GH axis without the confounding effects of other hormonal pathways.

  • Versatile Research Tool: Suitable for a wide range of studies, including:

    • Endocrinology: Research into growth hormone regulation, the hypothalamic-pituitary axis, and growth hormone deficiency.

    • Muscle Physiology: Studies on muscle growth, protein synthesis, and muscle wasting conditions (sarcopenia, cachexia).

    • Bone Metabolism: Research into bone density, bone formation, and osteoporosis.

    • Metabolic Disorders: Studies on metabolism, lipolysis, fat oxidation, and obesity.

    • Aging Research: Investigation into age-related decline in GH levels, sarcopenia, and metabolic health.

    • Neuroendocrinology: Research into the role of ghrelin and GHS-R1a in the central nervous system, including appetite regulation and neuroprotection.

    • Recovery & Repair: Studies on tissue repair, wound healing, and recovery from injury.

  • Practical Formulation: The lyophilized powder ensures stability and extended shelf life, while the included bacteriostatic water facilitates easy reconstitution for both in vitro and in vivo experiments.

Research & Science

Ipamorelin is a well-characterized growth hormone secretagogue with a distinct pharmacological profile that makes it particularly valuable for research applications.

  • Mechanism of Action: Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) that acts as a selective agonist at the growth hormone secretagogue receptor (GHS-R1a). Upon binding to this receptor, which is primarily located in the hypothalamus and pituitary gland, Ipamorelin:

    • Stimulates GH release from somatotroph cells in the anterior pituitary in a dose-dependent manner.

    • Acts synergistically with Growth Hormone-Releasing Hormone (GHRH) to amplify GH secretion.

    • Does not significantly affect cortisol, prolactin, or acetylcholine levels, making it more selective than other GHRPs like GHRP-2 or GHRP-6.

    • Increases serum IGF-1 levels as a downstream effect of elevated GH.

  • Pharmacological Profile: Compared to other GHRPs:

    • More selective for GH release with minimal cortisol or prolactin elevation.

    • Longer duration of action than GHRP-6.

    • No effect on gastric emptying or other gastrointestinal effects associated with ghrelin agonism.

  • Muscle & Bone Research: Studies have demonstrated that Ipamorelin:

    • Promotes protein synthesis and muscle growth in animal models.

    • Enhances bone mineral density and stimulates bone formation markers.

    • May protect against age-related muscle loss (sarcopenia) .

  • Metabolic Research: Ipamorelin has been shown to:

    • Promote lipolysis (fat breakdown) and fatty acid oxidation.

    • Improve metabolic efficiency and energy utilization.

    • Potentially improve insulin sensitivity in research models.

  • Aging Research: As GH and IGF-1 levels naturally decline with age, Ipamorelin is being investigated for its potential to partially restore GH levels and counteract age-related metabolic decline, including sarcopenia, reduced bone density, and decreased recovery capacity.

  • Neuroprotection: Ghrelin receptor signaling has been implicated in neuroprotection, and Ipamorelin's action at GHS-R1a makes it a relevant tool for studying the role of the ghrelin-GH axis in cognitive function and neural repair.

  • Focus on Genetic Variability: Research is exploring how genetic polymorphisms in the GHS-R1a gene, GH1 gene, and related signaling pathways may influence individual responses to Ipamorelin, opening avenues for personalized approaches to GH-related research.

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