{"product_id":"dinabolyn-methandienone","title":"Dinabolyn (Methandienone)","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eDinabolyn\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a research compound from Driada Medical, containing \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMethandienone\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e (also known as Methandrostenolone) \u003c\/span\u003e\u003ca href=\"https:\/\/histoirearchitecture19.uqam.ca\/dinabolyn-10-mg-driada-medical-todo-lo-que-necesitas-saber-sobre-su-uso-y-beneficios\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/wwwencyclopedia.thefreedictionary.com\/Methandrostenolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This is a synthetic anabolic-androgenic steroid (AAS) derived from testosterone. Its molecular formula is C₂₀H₂₈O₂ with a molecular weight of 300.4 g\/mol and a CAS number of 72-63-9 \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe compound features a \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e17α-alkylated structure\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e with a double bond between carbons 1 and 2 (Δ¹ modification) \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. These structural modifications serve specific research purposes:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e17α-methyl group\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e provides steric hindrance against hepatic oxidation, enabling oral bioavailability in research models \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B3359622\/docs#gc-ms-protocol-for-the-detection-of-methandrostenolone-using-methandrostenolone-d3\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eΔ¹ double bond\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e impedes 5α-reductase conversion, differentiating its receptor binding kinetics from non-Δ¹ androgens \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/wwwencyclopedia.thefreedictionary.com\/Methandrostenolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe product is intended for \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003elaboratory research use only\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and features an integrated QR code on the packaging for detailed product verification.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProduct Name:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Dinabolyn (Methandienone)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eBrand:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Driada Medical\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eForm:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Solution for research applications\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCAS:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e 72-63-9\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Research Use Only.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch Applications \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAndrogen Receptor Agonist:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Methandienone functions as an agonist at the androgen receptor (AR), the biological target of androgens like testosterone. Upon AR binding, the activated receptor-hormone complex translocates to the nucleus, binds to androgen response elements (AREs), and modulates transcription of genes involved in protein synthesis and cellular growth \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/wwwencyclopedia.thefreedictionary.com\/Methandrostenolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eQuantified Anabolic:Androgenic Ratio:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Relative to the testosterone baseline (100:100), Methandienone is characterized by an anabolic:androgenic ratio of \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e200:50\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its dissociation index is in the range of \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e2–3\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, compared to a range of 3–10 for several other anabolic agents \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This indicates a less selective anabolic profile relative to certain in-class alternatives \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/en.wikipedia.org\/api\/rest_v1\/page\/mobile-html\/Template:Relative_androgenic_to_anabolic_activity_in_animals\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProtein Anabolism Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The primary mechanism behind Methandienone's muscle-building capacity is its ability to increase \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eprotein synthesis\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and enhance \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003enitrogen retention\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e within muscle cells \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/wwwencyclopedia.thefreedictionary.com\/Methandrostenolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. A positive nitrogen balance (where nitrogen intake exceeds excretion) is a key indicator of an anabolic state \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This property can be studied in models of muscle physiology and metabolic research.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSHBG Affinity Studies:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Methandienone displays a very low affinity for human serum \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003esex hormone-binding globulin (SHBG)\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, quantified as approximately \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003e10% of testosterone's affinity and 2% of DHT's affinity\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This results in a significantly larger fraction of the compound circulating in the free, unbound state (the pharmacologically active form), influencing its bioavailability \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Methandienone's moderate androgenic and estrogenic effects \u003c\/span\u003e\u003ca href=\"https:\/\/wwwencyclopedia.thefreedictionary.com\/Methandrostenolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e provide avenues for research into lipid metabolism, glucose homeostasis, and endocrine regulation.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Scientific Background\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHistorical \u0026amp; Chemical Background:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Methandienone was first synthesized in 1955 by researchers at CIBA and introduced to the U.S. market in 1958. It is a 17α-alkylated derivative of testosterone \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/wwwencyclopedia.thefreedictionary.com\/Methandrostenolone\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. The C1-C2 double bond reduces its androgenic activity relative to its anabolic effects \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAndrogen Receptor Binding Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Computational docking studies of several oral anabolic steroids with the human androgen receptor ligand-binding domain (hARLBD) show that Methandienone registers a distinct binding energy profile, differentiating it from methyltestosterone, oxandrolone, and stanozolol in receptor interaction kinetics \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B1676361\/#immunohistochemistry-techniques-for-androgen-receptor-localization\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its rank order in AR binding affinity is situated differently from nandrolone and testosterone \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13989552\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHepatotoxicity Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The 17α-alkylated structure that confers oral bioavailability is also associated with potential hepatotoxic effects. Recent research (2026) demonstrates that metandienone exposure in HepG2 cells reduced cell viability to 88.01% and increased the apoptosis rate to 25.08%. RNA transcriptome data showed significant alteration of 221 genes closely related to liver metabolism, oxidative stress, and inflammatory response \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed-ncbi-nlm-nih-gov.jumper.tmu.edu.tw\/42286859\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.guidelinecentral.com\/pubmed\/42286859\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This makes Methandienone a key compound for studies on AAS-induced liver injury mechanisms.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolism \u0026amp; Detection Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Human excretion studies show that 6β-hydroxylation is a major metabolic pathway for Methandienone \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/product\/B13402039\/docs#technical-support-center-mitigating-methandrostenolone-induced-hepatotoxicity-in-animal-studies\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Recent research (2025) has identified novel metabolites, including E3 (17α-hydroxymethyl-17β-methyl-18-nor-5β-androsta-1,13-dien-3α-ol), which is being investigated as a potential long-term marker in anti-doping research \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40473058\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eGenetic Variability Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Research into genetic polymorphisms affecting metabolism is an emerging area. While direct studies on Methandienone are limited, the field of pharmacogenomics indicates that genetic variations in drug-metabolizing enzymes can influence compound response. Studies on compounds like methadone have shown that polymorphisms in genes such as \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCYP2B6\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCYP2C19\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, and \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eABCB1\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e can affect clearance and concentrations \u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7444627\/table\/T1\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/tapchiyhocvietnam.vn\/index.php\/vmj\/article\/view\/3162\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This suggests potential avenues for investigating how genetic factors may influence individual responses to Methandienone in research models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Driada","offers":[{"title":"Default Title","offer_id":58726415696197,"sku":null,"price":35.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/Driada-Dinabolyn.jpg?v=1785449442","url":"https:\/\/genetic-peps.shop\/products\/dinabolyn-methandienone","provider":"Genetic Peps","version":"1.0","type":"link"}