{"product_id":"clomilad-clomiphene-citrate","title":"Clomilad (Clomiphene Citrate)","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eClomilad\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a research compound from Driada Medical, containing \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eClomiphene Citrate\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e. Clomiphene Citrate is a nonsteroidal, orally active agent classified as a \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eselective estrogen receptor modulator (SERM)\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e . Its chemical formula is C₃₂H₃₆ClNO₈, with a molecular weight of 598.09 g\/mol .\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe compound functions as a mixed agonist-antagonist at estrogen receptors . By binding to estrogen receptors in the hypothalamus and pituitary, it blocks the negative feedback of estradiol, leading to increased release of gonadotropin-releasing hormone (GnRH) and subsequent elevation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) . This mechanism makes it a valuable research tool for studying the hypothalamic-pituitary-gonadal (HPG) axis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProduct Name:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Clomilad (Clomiphene Citrate)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eBrand:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Driada Medical\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eForm:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Solution for research applications\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCAS Number:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e 50-41-9\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Research Use Only.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch Applications \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eSelective Estrogen Receptor Modulator (SERM):\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Clomiphene is a benchmark compound for studying estrogen receptor (ER) biology due to its tissue-specific effects . It acts as an antagonist or weak agonist depending on the target tissue, making it valuable for investigating receptor dynamics and tissue-specific signaling . Its primary action is to bind to estrogen receptors in the hypothalamus and pituitary, blocking estradiol's negative feedback and stimulating gonadotropin release .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHypothalamic-Pituitary-Gonadal (HPG) Axis Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Clomiphene's ability to stimulate LH and FSH secretion makes it a key tool for studying the regulation of the HPG axis and gonadal function .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eReproductive Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e As a stimulator of gonadotropin release, clomiphene is used in research models to study spermatogenesis, ovarian function, and fertility mechanisms .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEndocrine Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The compound is used to study the feedback mechanisms of estrogen and the role of estrogen receptors in the hypothalamus and pituitary .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eComparative Studies:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Clomiphene's distinct pharmacology (mixed agonist\/antagonist) compared to pure antiestrogens makes it valuable for comparative studies of SERM activity .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Scientific Background\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMechanism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Clomiphene is a racemic mixture of two geometric isomers (zuclomiphene and enclomiphene) with differing activities . It binds to estrogen receptors (ERα and ERβ) in target tissues . In the hypothalamus and pituitary, the clomiphene-receptor complex blocks estradiol's negative feedback, leading to increased GnRH secretion and subsequent elevation of gonadotropin levels .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e The compound is extensively metabolized, primarily by cytochrome P450 enzymes (CYP3A4, CYP2D6), to active and inactive metabolites . The zuclomiphene isomer has a much longer half-life (approximately 30 days) compared to enclomiphene .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePharmacokinetics:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Following oral administration, clomiphene has a terminal elimination half-life of approximately 5-7 days for the total drug .\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Driada","offers":[{"title":"Default Title","offer_id":58726455345477,"sku":null,"price":35.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/Driada-Clomilad.jpg?v=1785450052","url":"https:\/\/genetic-peps.shop\/products\/clomilad-clomiphene-citrate","provider":"Genetic Peps","version":"1.0","type":"link"}