{"product_id":"caberos-cabergoline","title":"Caberos (Cabergoline)","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eAbout the Product\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCaberos\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e is a research compound from Driada Medical, containing \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCabergoline\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e. Cabergoline is a potent, long-acting dopamine receptor agonist with high affinity for the D2-like receptor family (D2R) \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/article\/MED\/40532573\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2025.1532414\/full\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its molecular formula is C₂₆H₃₇N₅O₂, with a molecular weight of 451.6 g\/mol. It is a synthetic ergoline derivative, structurally related to other ergot alkaloids \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022356524464604\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe compound functions primarily as a \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eD2-like receptor agonist\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, acting similarly to endogenous dopamine. This mechanism has made it a standard tool for research into the hypothalamic-pituitary-gonadal (HPG) axis and metabolic regulation \u003c\/span\u003e\u003ca href=\"http:\/\/www.hpra.ie\/img\/uploaded\/swedocuments\/ef99acf1-33be-453e-b864-0281466c82a7.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.medicines.org.uk\/emc\/files\/pil.1074.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2025.1532414\/full\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Cabergoline’s long half-life allows for intermittent dosing in research models, distinguishing it from other dopamine agonists \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0303720725000899\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/oupuser:T343mvvP@preview.academic.oup.com\/jes\/article\/9\/Supplement_1\/bvaf149.1573\/8298515\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe product is intended for \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003elaboratory research use only\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e and features an integrated QR code on the packaging for detailed product verification.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProduct Name:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Caberos (Cabergoline)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eBrand:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Driada Medical\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eForm:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Solution for research applications\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCAS Number:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e 81409-90-7\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFor Research Use Only.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch Applications \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePotent D2-like Receptor Agonist:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Cabergoline functions as a potent agonist at dopamine D2-like receptors (D2R, D3R, D4R) \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/article\/MED\/40532573\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2025.1532414\/full\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This binding activates inhibitory G-protein coupled signaling cascades, leading to decreased production of cyclic AMP and subsequent inhibition of target cell function \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2025.1532414\/full\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEndocrine \u0026amp; Reproductive Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Cabergoline is a benchmark compound for studying the HPG axis, particularly in models of hyperprolactinemia and prolactinomas. By activating D2R on pituitary lactotroph cells, cabergoline potently suppresses prolactin (PRL) secretion and reduces lactotroph cell proliferation \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0303720725000899\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/oupuser:T343mvvP@preview.academic.oup.com\/jes\/article\/9\/Supplement_1\/bvaf149.1573\/8298515\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/journal.einstein.br\/pt-br\/article\/a-new-and-useful-tool-for-differentiating-prolactinomas-from-non-functioning-pituitary-adenomas-a-pilot-study-of-the-cabergoline-disconnection-test\/#masthead\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Its ability to normalize prolactin levels and restore fertility makes it a key tool in reproductive endocrinology and developmental programming studies \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0303720725000899\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Cabergoline has demonstrated significant effects on body composition, energy balance, and lipid metabolism \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/article\/MED\/40532573\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Research applications include studying its role in reducing visceral adiposity, improving insulin sensitivity, and modulating lipid accumulation in both adipocytes and myocytes \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/article\/MED\/40532573\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/reachmd.com\/news\/unlocking-new-pathways-cabergolines-role-in-diabetes-management\/2482990\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2025.1532414\/full\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeuroscience \u0026amp; Neuroprotection:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Emerging research has highlighted cabergoline's potential neuroprotective and cognitive-enhancing properties \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0041008X2500167X\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn\/40349788\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Studies demonstrate that cabergoline can ameliorate cognitive decline, reduce neuroinflammation, and enhance autophagic clearance of pathological protein aggregates (Aβ42 and p-tau) in Alzheimer's disease models, primarily through modulation of AKT\/mTOR and GLT-1\/P38-MAPK signaling pathways \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0041008X2500167X\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn\/40349788\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This positions cabergoline as a compound of interest in drug repurposing studies for neurodegenerative conditions \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0041008X2500167X\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eReceptor Binding Studies:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Cabergoline is also used to study dopamine receptor binding dynamics and signaling selectivity. Its interaction with 5-HT2A and 5-HT2B serotonin receptors is of particular research interest, as this cross-reactivity is associated with the risk of fibrotic valvular heart disease (VHD) \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022356524464604\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Studies have demonstrated that the bulky N(6) allyl substituent of cabergoline is responsible for its agonism at these serotonin receptors, providing a molecular basis for structure-activity relationship (SAR) studies \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022356524464604\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eResearch \u0026amp; Scientific Background\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMechanism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Cabergoline’s primary mechanism is D2R agonism. In the pituitary, this inhibits prolactin release; in peripheral tissues, it influences metabolism through mechanisms involving central and peripheral targets, including the endocrine pancreas, adipose tissue, and skeletal muscle \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2025.1532414\/full\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Chronic administration has been shown to positively impact insulin secretion and sensitivity \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/article\/MED\/40532573\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. It has also been shown to induce autophagy, which may be relevant for clearing intracellular aggregates \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0041008X2500167X\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eReceptor Selectivity:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Cabergoline is not entirely selective for dopamine receptors. Research has shown that its bulky N(6) substituent also enables agonism at 5-HT2A and 5-HT2B serotonin receptors \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022356524464604\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This is a critical area of investigation, as agonism at 5-HT2B is linked to valvular heart disease \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022356524464604\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. The drug's profile at native serotonin receptors suggests these may not be the primary driver of VHD in vivo, but the interaction remains a significant research consideration \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022356524464604\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePharmacogenomics:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Inter-individual variability in cabergoline response is a growing area of research. Genetic factors influencing the dose-response relationship have been identified. For instance, in a prospective study of 310 prolactinoma patients, dose-response curves demonstrated that effective weekly doses varied significantly based on patient history and tumor characteristics (e.g., ED50 of 0.66 mg\/week for bromocriptine-intolerant patients, 1.36 mg\/week for naïve patients, and 3.30 mg\/week for bromocriptine-resistant patients) \u003c\/span\u003e\u003ca href=\"https:\/\/oupuser:T343mvvP@preview.academic.oup.com\/jes\/article\/9\/Supplement_1\/bvaf149.1573\/8298515\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. This indicates a clear potential for genetic and phenotypic factors to influence treatment sensitivity.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Driada","offers":[{"title":"Default Title","offer_id":58726481690949,"sku":null,"price":40.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/Driada-Caberos.jpg?v=1785450482","url":"https:\/\/genetic-peps.shop\/products\/caberos-cabergoline","provider":"Genetic Peps","version":"1.0","type":"link"}