{"product_id":"allaes-ibutamoren-mk-677","title":"Allaes Ibutamoren (MK-677)","description":"\u003ch4\u003e\u003cspan class=\"\"\u003eSobre o Produto\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAllaes Ibutamoren\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e é um composto de investigação da Driada Medical, contendo \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIbutamoren (MK-677)\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e. O Ibutamoren é um secretagogo da hormona de crescimento (GH) potente, de administração oral e não peptídico, que atua como um agonista do recetor da grelina (GHS-R1a) \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Application_Notes_and_Protocols_for_In_Vitro_Cell_Culture_Studies_with_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/The_Ghrelin_Receptor_s_Embrace_A_Technical_Guide_to_the_Mechanism_of_Action_of_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. A sua fórmula molecular é C₂₇H₃₆N₄O₅S, com um peso molecular de 528.66 g\/mol.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eO composto distingue-se por ser um \u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003emimetizador da grelina\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, estimulando a libertação pulsátil da hormona de crescimento (GH) e, consequentemente, aumentando os níveis de Fator de Crescimento Semelhante à Insulina-1 (IGF-1) \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Application_Notes_and_Protocols_for_In_Vitro_Cell_Culture_Studies_with_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/The_Ghrelin_Receptor_s_Embrace_A_Technical_Guide_to_the_Mechanism_of_Action_of_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Esta ação torna-o uma ferramenta valiosa para a investigação do eixo GH\/IGF-1.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eApenas para Utilização em Investigação Laboratorial. Não para consumo humano.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNome do Produto:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Allaes Ibutamoren (MK-677)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMarca:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Driada Medical\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eForma:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Solução para aplicações de investigação\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNº CAS:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e 159752-10-0 \u003c\/span\u003e\u003ca href=\"https:\/\/www.fda.gov\/media\/182087\/download#14#14\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eApenas para Utilização em Investigação.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eAplicações em Investigação e Mecanismo de Ação\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAgonista do Recetor da Grelina (GHS-R1a):\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e O Ibutamoren funciona como um agonista potente e seletivo do recetor da grelina (GHS-R1a). Ao contrário da grelina endógena, é um composto estável e biodisponível por via oral, tornando-o adequado para protocolos de investigação que requerem administração não invasiva \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Application_Notes_and_Protocols_for_In_Vitro_Cell_Culture_Studies_with_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/The_Ghrelin_Receptor_s_Embrace_A_Technical_Guide_to_the_Mechanism_of_Action_of_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/The_Genesis_and_Synthesis_of_a_Potent_Growth_Hormone_Secretagogue_A_Technical_Guide_to_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAtivação do Eixo GH\/IGF-1:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e A ativação do GHS-R1a desencadeia cascatas de sinalização (Gαq\/11 e Gi\/o), levando à libertação de GH da hipófise. Este GH estimula subsequentemente a produção hepática de IGF-1, o principal mediador dos efeitos anabólicos da GH \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Application_Notes_and_Protocols_for_In_Vitro_Cell_Culture_Studies_with_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/The_Ghrelin_Receptor_s_Embrace_A_Technical_Guide_to_the_Mechanism_of_Action_of_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Estudos demonstraram que o MK-677 (25 mg\/dia) aumenta a concentração média de GH em 97% e restaura os níveis de IGF-1 para a gama de adultos jovens em indivíduos idosos \u003c\/span\u003e\u003ca href=\"https:\/\/mayoclinic.elsevierpure.com\/en\/publications\/stimulation-of-the-growth-hormone-gh-insulin-like-growth-factor-i\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eInvestigação do Eixo Hormonal:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Devido à sua via de ação bem definida, o Ibutamoren é utilizado para estudar o eixo GH\/IGF-1, a regulação da grelina e os mecanismos de feedback envolvidos na homeostase energética \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Application_Notes_and_Protocols_for_In_Vitro_Cell_Culture_Studies_with_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.kci.go.kr\/kciportal\/ci\/sereArticleSearch\/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002404631\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEstudos Metabólicos e de Composição Corporal:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e A sua capacidade de aumentar a massa magra e influenciar o metabolismo faz dele uma ferramenta para a investigação de condições como a sarcopenia e a obesidade \u003c\/span\u003e\u003ca href=\"https:\/\/www.fda.gov\/media\/182087\/download#14#14\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.sportintegrity.gov.au\/what-we-do\/anti-doping\/substance-education\/ibutamoren-mk-677-information\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeurociência:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Dado o papel neuroprotetor do IGF-1, o Ibutamoren tem sido investigado em modelos de declínio cognitivo associado à idade e doença de Alzheimer. Embora tenha demonstrado aumentar a neurogénese e reduzir a deposição de Aβ num modelo 5XFAD, não melhorou significativamente a cognição num ensaio clínico de fase 3 \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/Application_of_Ibutamoren_MK_677_in_Studies_of_Age_Related_Cognitive_Decline_Application_Notes_and_Protocols.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch4\u003e\u003cspan class=\"\"\u003eInvestigação \u0026amp; Contexto Científico\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eDescoberta e Desenvolvimento:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e O Ibutamoren (MK-677) foi originalmente desenvolvido pela Merck Research Laboratories como um secretagogo da hormona de crescimento não peptídico com biodisponibilidade oral \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/The_Genesis_and_Synthesis_of_a_Potent_Growth_Hormone_Secretagogue_A_Technical_Guide_to_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. Continua a ser um composto de investigação, sem aprovação para consumo humano \u003c\/span\u003e\u003ca href=\"https:\/\/www.getsmartaboutdrugs.gov\/news-statistics\/2025\/07\/08\/beyond-hype-potential-health-risks-mk-677\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.sportintegrity.gov.au\/what-we-do\/anti-doping\/substance-education\/ibutamoren-mk-677-information\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFarmacocinética:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e O MK-677 é administrado por via oral, com uma ação prolongada. Tem uma alta afinidade pelo recetor GHS-R1a, com um valor de Ki calculado de ~7.24 nM e uma EC50 de 1.3 nM para a libertação de GH em células hipofisárias de rato \u003c\/span\u003e\u003ca href=\"https:\/\/www.benchchem.com\/pdf\/The_Ghrelin_Receptor_s_Embrace_A_Technical_Guide_to_the_Mechanism_of_Action_of_Ibutamoren_MK_677.pdf#1#1\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEvidência de Estudos Clínicos:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Num ensaio randomizado, duplo-cego e controlado por placebo, a administração de MK-677 (25 mg\/dia) em indivíduos idosos saudáveis durante 4 semanas aumentou significativamente os níveis séricos de GH e IGF-1 \u003c\/span\u003e\u003ca href=\"https:\/\/mayoclinic.elsevierpure.com\/en\/publications\/stimulation-of-the-growth-hormone-gh-insulin-like-growth-factor-i\/\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. No entanto, estudos em ratos com administração prolongada (6 semanas) mostraram que o efeito estimulador da GH pode diminuir ao longo do tempo, possivelmente relacionado com o aumento da expressão de somatostatina (SST) \u003c\/span\u003e\u003ca href=\"https:\/\/www.kci.go.kr\/kciportal\/ci\/sereArticleSearch\/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002404631\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eRiscos Potenciais para a Investigação:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e Tal como outros secretagogos, o Ibutamoren pode causar aumento do apetite, retenção de água, e resistência à insulina \u003c\/span\u003e\u003ca href=\"https:\/\/www.getsmartaboutdrugs.gov\/news-statistics\/2025\/07\/08\/beyond-hype-potential-health-risks-mk-677\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.sportintegrity.gov.au\/what-we-do\/anti-doping\/substance-education\/ibutamoren-mk-677-information\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e. A sua utilização em modelos de investigação requer monitorização dos níveis de glucose e IGF-1, bem como consideração dos seus efeitos no metabolismo e no sistema cardiovascular \u003c\/span\u003e\u003ca href=\"https:\/\/www.getsmartaboutdrugs.gov\/news-statistics\/2025\/07\/08\/beyond-hype-potential-health-risks-mk-677\" rel=\"noreferrer\" style=\"cursor: default;\" target=\"_blank\"\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Driada","offers":[{"title":"Default Title","offer_id":58726476382533,"sku":null,"price":55.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1077\/7614\/7781\/files\/Driada-AllaesIbutamoren_MK-677.jpg?v=1785450268","url":"https:\/\/genetic-peps.shop\/products\/allaes-ibutamoren-mk-677","provider":"Genetic Peps","version":"1.0","type":"link"}